WHEY PROTEIN DIARRHEA CLOSE TO DUE DATE PLUS

Recent studies suggest that whey protein concentrates (WPC), fractions, or individual peptides present in milk and colostrum might be useful for the treatment of a wide variety of gastrointestinal disorders, such as inflammatory bowel disease, necrotizing enterocolitis, and infective diarrhea ( 8). Based on these premises, the interest in including whey protein products as functional food ingredients has increased over the last years ( 6). Colostrum is the first milk produced by mammals after birth and it is richer in these bioactive molecules than mature milk ( 7).

The bactericidal proteins in milk, such as lysozyme and lactoferrin (LF), 6 as well as growth factors, nucleotides, hormones, and cytokines, improve immune defense and gut-barrier function ( 5, 6). These act by binding to and neutralizing pathogens in the intestinal tract. In addition to providing passive protection from the mother, in which maternal Ig passes through the placenta into the circulation of the developing fetus ( 3), breast milk stimulates the infant's immune system, particularly in the gastrointestinal tract, during the most critical period for the neonate, the first days of life ( 4).ДЄlthough the composition of mammary secretions changes throughout the suckling period, the most beneficial effects on immune health of the compounds comprising milk are obtained from the high proportion of Ig. In summary, daily supplementation with WPC or WPC+LF in early life considerably reduces the severity of RV-induced acute gastroenteritis and modulates the immune response against the pathogen.Д«reast milk is the most important and beneficial food during early infancy, not only because of its nutritional value but also because of its ability to modulate the immune system during this period ( 1, 2). In general, for most of the parameters studied, the SIF-RV and RV groups did not differ. In the intraepithelial intestinal compartment, RV infection increased the proportion of typical mucosal T cells (IE-T CD8 О±О±+) however, this modification was controlled by WPC and WPC+LF supplementation. Serum levels of anti-RV antibodies, splenocyte proliferation, and interferon- Оі secretion after specific stimulation were significantly lower in the WPC-RV and WPC+LF-RV groups than in the SIF-RV and RV groups. WPC and WPC+LF reduced diarrhea incidence from в€ј90% in RV group to в€ј60% in WPC-RV and WPC+LF-RV groups ( P < 0.05), whereas the area under the curve (AUC) of severity along time diminished from в€ј10 AUC in the RV group to в€ј6 AUC in both supplemented groups ( P < 0.05). On d 8 of life, heterologous simian RV SA-11 was inoculated orally in the WPC-RV, WPC+LF-RV, SIF-RV, and RV groups.

WHEY PROTEIN DIARRHEA CLOSE TO DUE DATE PLUS

From d 3 of life, suckling Lewis rats received daily supplements of WPC, WPC plus lactoferrin (LF), standard infant formula (SIF), or water (RV-infected group and an untreated, uninfected reference group). The present study was designed to establish the effect of a bovine whey protein concentrate (WPC) in a RV infection model in suckling rats. Group A rotaviruses (RV) are the most common causative agents of acute gastroenteritis in children <2 y.

Whey protein diarrhea close to due date